赵涵

作者:时间:2020-11-12点击数:

赵涵(兼职)


最高学历、学位:研究生、博士

职称:研究员

职务:江苏省农业科学院种质资源与生物技术研究所所长

电子邮箱:zhaohan@jaas.ac.cn


一、基本情况

2006年美国密歇根州立大学遗传育种学博士毕业后赴美国伊利诺伊大学博士后工作,2010年江苏省农科院引进人才,现为江苏省农业科学院种质资源与生物技术研究所所长,兼分子育种研究室主任,江苏省农业科学院博士后工作站博士后导师。

二、主要研究领域及学术成就

主要从事作物分子生物学及生物信息学研究,在玉米基因组大数据分析、下一代测序数据生物信息学,分子标记开发等方面开展了大量的工作, 与国内外近十家单位建立了良好的合作关系。目前,主持、参加国家重点研发计划,国家转基因专项和国家自然科学基金等多个项目,发表包括SCI在内的论文45余篇,申请专利及软件著作权近22项,授权15项。

三、代表性科研成果

发表论文:

[1] High-resolution profile of transcriptomes reveals a role of alternative splicing for modulating response to nitrogen in maize. BMC Genomics, 2020, 21: 353

[2] A cost-effective barcode system for maize genetic discrimination based on bi-allelic InDel markers. Plant Methods, 2020, 16:101

[3] The NIN-like protein 5 (ZmNLP5) transcription factor is involved in modulating the nitrogen response in maize. The Plant Journal, 2019, 14628

[4] A sequence-indexed Mutator insertional library for maize functional genomics study. Plant Physiol, 2019, 181:1404–1414

[5] QTL mapping for maize starch content and candidate gene prediction combined with co–expression network analysis. Theoretical and Applied Genetics, 2019, 132:1931–1941

[6] OPAQUE11 is a central hub of the regulatory network for maize endosperm development and nutrient metabolism. The Plant Cell, 2018, 30: 375–396

[7] Genome-wide analysis of maize NLP transcription factor family revealed the roles in nitrogen response. Plant Growth Regul, 2018, 84: 95–105

[8] Analysis of gene regulatory networks of maize in response to nitrogen. Genes, 2018, 9, 151

[9] A role of ETR1 in regulating leaf petiole elongation mediated by elevated temperature in Arabidopsis. Plant Growth Regul, 2018, 86:311–321

[10] Development of oligonucleotides and multiplex probes for quick and accurate identification of wheat and Thinopyrum bessarabicum chromosomes. Genome, 2017, 60: 93–103

[11] Development of novel InDel markers and genetic diversity in Chenopodium quinoa through whole-genome re-sequencing. BMC Genomics, 2017, 18:685

[12] A simple and efficient non-denaturing FISH method for maize chromosome differentiation using single-strand oligonucleotide probes. Genome, 2017, 60: 657–664

[13] Genome-wide discovery of tissue-specific genes in maize. Plant Mol Biol Rep, 2016, 34:1204–1214

[14] Genome-wide identification and functional prediction of nitrogen-responsive intergenic and intronic long non-coding RNAs in maize (Zea mays L.). BMC Genomics, 2016, 17:350

[15] mInDel: a high-throughput and efficient pipeline for genome-wide InDel marker development. BMC Genomics, 2016, 17:290

[16] High-throughput development of simple sequence repeat markers for genetic diversity research in Crambe abyssinica. BMC Plant Biology 2016, 16:139

[17] Analysis of heterosis and quantitative trait loci for kernel shape related traits using triple testcross population in maize. Plos One, 2015, 4 (10): e0124779

[18] Identification and characterization of presence/absence variation in maize genotype Mo17. Genes & Genomics, 2015, 6 (37): 503–515

[19] Genome-wide characterization of cis-acting DNA targets reveals the transcriptional regulatory framework of Opaque2 in maize. Plant Cell, 2015, 27:532–545

[20] Screening for recombinants of Crambe abyssynica after transformation by the pMF1 marker-free vector based on chemical selection and meristematic regeneration. Scientific Reports 2015, 5:14033

[21] Genome-wide histone acetylation correlates with active transcription in maize. Genomics, 2015, 106: 214–220

[22] Lin F, Jiang L, Liu Y, Lv Y, Dai H, Zhao H. Genome-wide identification of housekeeping genes in maize. Plant Mol Biol 2014, 86:543–554

[23] Construction of a linkage map for quantitative trait loci associated with economically important traits in creeping bentgrass (Agrostis stolonifera L.). Euphytica, 2012, 188(3): 347–360

[24]基于高通量测序开发玉米高效KASP分子标记.作物学报, 2019, 45:872–878

[25]基于DAP-Seq方法鉴定玉米胚乳特异表达转录因子O2在全基因组水平上的结合位点.科学通报, 2019, 64:2537–2548

[26]藜麦的耐盐性评价及在滨海盐土的试种表现.核农学报, 2017, 31:0145–0155

[27]调控玉米阻止授粉后叶片衰老的QTL定位.江苏农业学报, 2017, 33(4): 747–753

[28]基于三重测交群体解析玉米株高与穗位高杂种优势QTL.核农学报, 2017, 31:0837–0843

[29]中国黄淮海地区玉米杂种优势候选位点的鉴定.玉米科学, 2017, 25: 15–23

[30]玉米籽粒蛋白含量Meta-QTL及候选基因分析.江苏农业学报, 2016, 32:736–745

[31]玉米氮素敏感性差异自交系的表达谱分析.作物学报, 2016, 42:1487–1494

[32]玉米Glyco-hydro-16糖苷酶家族全基因组的鉴定及其遗传分化.中国农业科学, 2016, 49(11):2039–2048

[33]藜麦EST-SSR的开发及通用性分析.作物学报, 2016, 42(4): 492–500

[34]基于基因组重测序信息构建玉米第5染色体的片段代换系.玉米科学, 2015, 23(6):21–26

[35]玉米自交系的遗传多样性分析及杂种优势群划分.江苏农业科学, 2015,43(11):107–109

[36]玉米Dof转录因子家族的全基因组鉴定与分析.中国农业科学, 2014, 47(23): 4563–4572

[37]玉米YABBY基因家族的全基因组鉴定与分析.江苏农业学报, 2014, 30(6): 1267–1272

[38]基于全基因组重测序信息开发玉米H99自交系特异分子标记.作物学报, 2014, 40(2): 191–197

[39]玉米籽粒主要性状与蛋白质含量的相关性.江苏农业科学, 2014, 42(12): 104–106

[40]利用Insertion/Deletion(InDel)分子标记检测玉米互交种混杂的原理及应用.分子植物育种, 2013, 11(1): 37–47

[41]农杆菌介导玉米H99遗传转化体系的优化.玉米科学, 2013, 21(6): 31–34

[42]利用玉米高通量RNA-Seq数据预测长链非编码RNA (LncRNA).江苏农业学报, 2013, 29(6): 1248–1253

[43]农杆菌介导Cry1 Ab/Ac抗虫转基因玉米植株的获得.江苏农业学报, 2012, 28(2): 254–258

[44]玉米功能性Insertion/Deletion(InDel)分子标记的挖掘及其在杂交种纯度鉴定中的应用.玉米科学, 2012, 20(2): 64–68

授权专利:

[1]控制玉米氮响应的基因及其应用.专利号:ZL201610910526.2

[2]利用分子标记鉴定玉米互交种的方法.专利号: ZL201210256500.2

[3]控制基因在玉米籽粒中特异表达的启动子及其获得方法和应用.专利号:ZL201610320065.3

[4]调控玉米籽粒长度主效QTL的分子标记及其应用.专利号:ZL201410462801.X

[5]一种寡核苷酸染液及其应用与用法.专利号:ZL201611130825.0

[6]藜麦EST-SSR分子标记及开发方法与应用.专利号: ZL201510595296.0

[7]藜麦二态性InDel分子标记及其开发方法与利用.专利号:ZL201710282117.7

申请专利:

[1]检测增强型绿色荧光蛋白基因的引物及其筛选方法与应用.申请号: 201410696383.0

[2]玉米NLP转录因子ZmNLP5及其应用.申请号:201811413552.X

[3]高通量筛选玉米内参基因的方法.申请号: 201410396506.9

[4]玉米淀粉含量主效QTL位点的分子标记及应用.申请号:201710303443.1

[5]玉米第4号染色体穗行数的主效QTL分子标记、辅助选择多穗行玉米的方法及其应用.申请号:201710283069.3

[6]与玉米行粒数主效QTL紧密连锁的分子标记及其应用.申请号:201710284306.8

软件著作权登记:

[1]转录组共表达网络分析软件v1.0.登记号:2017SR526883

[2]BSA-Seq混池测序分析软件v1.0.登记号:2017SR526867

[3]KASP引物设计软件v1.0.登记号:2017SR526877

[4]Mu转座子插入位点检测程序V1.0.登记号: 2014SR071117

[5]PAV变异检测软件v1.0.登记号:2017SR526872

[6]SSR基因分型软件v1.0.登记号:2017SR526598

[7]分子标记遗传评价软件V1.0.登记号:2016SR232856

[8]高通量InDel分子标记开发系统V1.0.登记号: 2014SR071220

[9]高通量SNP变异检测程序V1.0.登记号: 2014SR070876

[10]高通量位点特异性引物设计软件V1.0.登记号: 2014SR089242

[11]高通量转录组定量分析软件V1.0.登记号:2016SR232880

[12]基于kmer值的特异性引物设计软件V1.0.登记号: 2014SR089227

[13]基于大规模SNP数据构建系统进化树程序V1.0.登记号: 2014SR071217

[14]转基因外源片段插入位点检测软件V1.0.登记号:2016SR232852

[15]高通量HPSSR分子标记开发系统v1.0.登记号:2016SR232860

[16]基因家族自然突变位点筛选软件v1.0.登记号:2017SR526894

[17]全基因组水平基因家族分析软件v1.0.登记号:2017SR526663

[18]玉米杂种优势位点挖掘软件v1.0.登记号:2016SR228981

立项省地方标准:

[1]玉米品种真实性及纯度检测技术规程SNP标记法


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